70 articles for M Bartolini
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Article Title
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Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
University of Bologna
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.
Alma Mater Studiorum-University of Bologna
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.
University of Bras£Lia
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.
China Pharmaceutical University
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.
University of Bologna
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-ß aggregation and to exert anticholinesterase and antioxidant effects.
Alma Mater Studiorum-University of Bologna
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
Universitat De Barcelona
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.
University of Bologna
Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.
University of Siena
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
Universitat De Barcelona
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.
University of Bologna
Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.
University of Bologna
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.
University of Bologna
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
Universitat De Barcelona
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.
University of Bologna
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.
University of Bologna
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
University of Bologna
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
University of Bologna
Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.
University of Bologna
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.
University of Lisbon
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.
University of Bologna
Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.
Institut F£R Molekulare Physiologie
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
University of Bologna
Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.
Department of Pharmaceutical Sciences-Alma Mater Studiorum-Bologna University
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.
University of Bologna
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
University of Bologna
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.
Alma Mater Studiorum-Bologna University
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
University of Bologna
Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.
University of Bologna
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.
University of Bologna
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties.
Alma Mater Studiorum - University of Bologna
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.
Bologna University
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.
University of Bologna
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3.
Institute of Organic Synthesis and Photoreactivity - National Research Council
Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease.
Alma Mater Studiorum - University of Bologna
Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.
University of Bologna
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
University of Barcelona (Ub)
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties.
University of Bras£Lia
Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads.
Alma Mater Studiorum - University of Bologna
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
University of Bologna
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.
Alma Mater Studiorum - University of Bologna
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
University of Barcelona
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
University of Bologna
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.
University of Barcelona (Ub)
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.
University of Barcelona
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
University of Hradec Kralove
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Cnrs
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.
Alma Mater Studiorum-University of Bologna
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Universidad De Sevilla
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.
Julius Maximilian University of W£Rzburg
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Alexandria University
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
University of Barcelona
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.
Alma Mater Studiorum University of Bologna
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.
Universidad De Sevilla
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.
Laboratory of Medicinal Chemistry (Iqog, Csic)
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors.
Alma Mater Studiorum-University of Bologna
New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.
Sapienza University of Rome
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.
Alma Mater Studiorum-University of Bologna
Substituted pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the same
Nissan Chemical Industries
Substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
Hoffmann-La Roche
Compounds and compositions for treating HIV with derivatives of Betulin
Glaxosmithkline
A practical synthesis of the major 3-hydroxy-2-pyrrolidinone metabolite of a potent CDK2/cyclin A inhibitor.
Nerviano Medical Sciences
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Merck Research Laboratories
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones.
Boehringer Ingelheim Pharmaceuticals