31 articles for M Inoue
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase.
Nagasaki University
Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558.
Daiichi Sankyo
Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability.
Astellas Pharma
Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain.
Astellas Pharma
Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
Shionogi
Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-a agonistic activity.
Aichi Gakuin University
Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.
Aichi Gakuin University
Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels.
Astellas Pharma
Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists.
Daiichi Sankyo
Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).
Shionogi
Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
TBA
Synthesis and SAR studies of bicyclic amine series GPR119 agonists.
Sanwa Kagaku Kenkyusho
Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases.
Shionogi
Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.
Aichi Gakuin University
Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2.
Tokushima Bunri University
Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase.
Japan Tobacco
Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
Japan Tobacco
Oral Nonpeptidic, Noncovalent Triazine Coronavirus Main Protease Inhibitors for Treating COVID-19.
Experimental Drug Development Centre
Addition of hydrophobic side chains improve the apoptosis inducibility of the human glyoxalase I inhibitor, TLSC702.
Tokyo University of Science
Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.
Japan Tobacco
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
Frederick National Laboratory For Cancer Research
Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.
University of California
INHIBITORS AND DEGRADERS OF JANUS KINASE 2
H. Lee Moffitt Cancer Center and Research Institute
Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
H. Lundbeck
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .
Weill Cornell Medical College
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.
Cnrs Ccipe
Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.
Academia Sinica