50 articles for D Merk
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Cmpds
Data
Article Title
Organization
10
Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.
Goethe-University Frankfurt
49
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor¿ Modulators.
Goethe-University Frankfurt
44
Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.
Goethe-University Frankfurt
12
Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties.
Goethe-University Frankfurt
38
Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist.
Goethe-University Frankfurt
12
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR).
Goethe-University Frankfurt
35
A Nurr1 Agonist Derived from the Natural Ligand DHI Induces Neuroprotective Gene Expression.
Ludwig-Maximilians-Universite
27
Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools.
Ludwig-Maximilians-Universitat (LMU) Munchen
20
Tuning RXR Modulators for PGC1α Recruitment.
Ludwig-Maximilians-Universitat (LMU) Munchen
31
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties.
Ludwig-Maximilians-Universitat (LMU) Munchen
45
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism.
Ludwig-Maximilians-University of Munich
2
Development of a Potent and Selective G2A (GPR132) Agonist.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
29
Exploring Fatty Acid Mimetics as NR4A Ligands.
Ludwig Maximilian University of Munich
27
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications.
Ludwig Maximilian University of Munich
10
Structural Fusion of Natural and Synthetic Ligand Features Boosts RXR Agonist Potency.
Goethe University Frankfurt
11
Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole.
Ludwig Maximilian University of Munich
21
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ.
Goethe University Frankfurt
8
The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators.
Goethe University Frankfurt
18
Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.
Goethe University Frankfurt
20
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.
Goethe University Frankfurt
52
Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.
Goethe-University
7
Design of a Potent TLX Agonist by Rational Fragment Fusion.
Goethe University Frankfurt
5
Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator.
Goethe University
28
Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics.
Goethe University Frankfurt
22
A Photohormone for Light-Dependent Control of PPARα in Live Cells.
Goethe-University Frankfurt
12
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
Goethe-University Frankfurt
29
Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.
Goethe University Frankfurt
42
Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.
Goethe-University Frankfurt
16
Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms.
Goethe University
16
A New FXR Ligand Chemotype with Agonist/Antagonist Switch.
Goethe-University Frankfurt
13
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ).
New York University
21
Design and Structural Optimization of Dual FXR/PPARδ Activators.
Goethe University Frankfurt
7
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ.
Goethe-University Frankfurt
5
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.
Goethe-University Frankfurt
32
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.
Goethe University Frankfurt
1
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds.
Goethe University Frankfurt
27
Structure optimization of a new class of PPARγ antagonists.
Fraunhofer Institute For Molecular Biology and Applied Ecology Ime
19
A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode.
Goethe-University Frankfurt
30
Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype.
Goethe-University Frankfurt
20
A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.
Goethe-University Frankfurt
5
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
Goethe-University Frankfurt
10
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Goethe University Frankfurt
24
Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists.
Goethe-University Frankfurt
10
Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics.
Swiss Federal Institute of Technology (Eth)
4
DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators.
Goethe-University Frankfurt