53 articles for W Sippl
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.
Martin-Luther University of Halle-Wittenberg
KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases.
University of Freiburg
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
Albert-Ludwigs-University of Freiburg
Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.
Albert-Ludwigs-University of Freiburg
Discovery of 4-anilinoa-carbolines as novel Brk inhibitors.
Martin-Luther-University Halle-Wittenberg
Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.
University of Freiburg
Evaluation of potential Myt1 kinase inhibitors by TR-FRET based binding assay.
Martin-Luther-University Halle-Wittenberg
Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).
Ludwig-Maximilians-Universit£T M£Nchen
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).
University of Freiburg
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.
Albert-Ludwigs-University of Freiburg
A novel arginine methyltransferase inhibitor with cellular activity.
Albert-Ludwigs-University of Freiburg
Target-based approach to inhibitors of histone arginine methyltransferases.
Albert-Ludwigs-University of Freiburg
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.
Louis Pasteur University
In vitro and in silico studies on substrate recognition and acceptance of human PKMYT1, a Cdk1 inhibitory kinase.
Martin-Luther-University Halle-Wittenberg
Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.
Albert-Ludwigs-University of Freiburg
Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors.
Albert-Ludwigs-University of Freiburg
Computer- and structure-based lead design for epigenetic targets.
Martin-Luther University of Halle-Wittenberg
Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).
University of East Anglia
Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.
Martin-Luther-University Halle-Wittenberg
Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors.
Chulalongkorn University
Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the ataxia telangiectasia and RAD3-related (ATR) kinase.
Martin-Luther-University of Halle-Wittenberg
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.
University of Bayreuth
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2.
University of Freiburg
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.
Leipzig University
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Albert-Ludwigs-University of Freiburg
Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties.
Martin-Luther University of Halle-Wittenberg
Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.
Martin-Luther University of Halle-Wittenberg
Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.
Yeditepe University
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
Martin-Luther University of Halle-Wittenberg
N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.
Johann Wolfgang Goethe-UniversitäT
Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations.
Ludwig-Maximilians University
Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.
Martin-Luther University of Halle-Wittenberg
Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Different antagonist binding properties of human and rat histamine H3 receptors.
Freie UniversitäT Berlin
Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies.
University of Hamburg
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.
Ludwig-Maximilians University Munich
Computer-aided design, synthesis and biological characterization of novel inhibitors for PKMYT1.
Martin-Luther-University Halle-Wittenberg
Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position.
University Munster
Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
3D-QSAR CoMFA/CoMSIA models based on theoretical active conformers of HOE/BAY-793 analogs derived from HIV-1 protease inhibitor complexes.
Universidade Federal De Lavras
Unexpected AChE inhibitory activity of (2E)α,β-unsaturated fatty acids.
Martin-Luther-University Halle-Wittenberg
Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation.
University of Freiburg
Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II.
Martin-Luther-University Halle-Wittenberg
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).
University of Freiburg
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
University of Strasbourg
Potent and Selective Inhibitors of Human Sirtuin 5.
Martin-Luther-University Halle-Wittenberg
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.
Martin-Luther University of Halle-Wittenberg