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Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1.

Procter and Gamble Pharmaceuticals
Synthesis and In Vitro evaluation of fused ring heterocyle-containing angiotensin II antagonists.

TBA
Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3).

Procter and Gamble Pharmaceuticals
Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.

Procter and Gamble Pharmaceuticals
Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.

Procter and Gamble Pharmaceuticals
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.

Procter & Gamble Pharmaceuticals
Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases.

TBA
Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.

Procter and Gamble Pharmaceuticals
Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.

Procter and Gamble Pharmaceuticals
Discovery of potent, achiral matrix metalloproteinase inhibitors.

Procter and Gamble Pharmaceuticals
2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists.

Abbott Laboratories
Heterocycle-based MMP inhibitors with P2' substituents.

Procter and Gamble Pharmaceuticals
Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.

Procter & Gamble Pharmaceuticals
The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).

Procter and Gamble Pharmaceuticals
Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.

Procter & Gamble Pharmaceuticals
The development of novel 1,2-dihydro-pyrimido[4,5-c]pyridazine based inhibitors of lymphocyte specific kinase (Lck).

Procter and Gamble Pharmaceuticals
Development of N-4,6-pyrimidine-N-alkyl-N'-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase.

Procter & Gamble Pharmaceuticals
Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors.

Procter & Gamble Pharmaceuticals
The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.

Procter and Gamble Pharmaceuticals
The development of new bicyclic pyrazole-based cytokine synthesis inhibitors.

Procter and Gamble Pharmaceuticals
Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis.

Procter & Gamble Pharmaceuticals
The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold.

Procter and Gamble Pharmaceuticals
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.

Procter and Gamble Pharmaceuticals
Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines.

Procter and Gamble Pharmaceuticals
Design and synthesis of 13,14-dihydro prostaglandin F(1alpha) analogues as potent and selective ligands for the human FP receptor.

Procter and Gamble Pharmaceuticals
Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.

Procter and Gamble Pharmaceuticals
Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold.

University of Florida
Design and synthesis of conformationally-constrained MMP inhibitors.

Procter and Gamble Pharmaceuticals
The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production.

Procter and Gamble Pharmaceuticals
Development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor-alpha production.

Procter and Gamble Pharmaceuticals
LH-RH antagonists: design and synthesis of a novel series of peptidomimetics.

Abbott Laboratories
Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.

Abbott Laboratories