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80 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.EBI
University of Arizona
Novel diazabicycloalkane delta opioid agonists.EBI
Istituto Di Farmacologia Traslazionale
Design, synthesis, and structure-activity relationship of novel opioid┐ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.EBI
Kitasato University
Synthesis and Pharmacology of a Novel┐ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.EBI
Kitasato University
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14▀-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.EBI
Virginia Commonwealth University
Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies.EBI
National Research Council
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.EBI
Kitasato University
Novel delta opioid receptor agonists with oxazatricyclodecane structure.EBI
Kitasato University
Design, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potentµ-opioid agonists.EBI
Lanzhou University
The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives.EBI
Kitasato University
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).EBI
Kitasato University
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.EBI
Kitasato University
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants.EBI
Memorial Sloan-Kettering Cancer Center
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.EBI
TBA
Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands.EBI
Kitasato University
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.EBI
Kitasato University
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.EBI
Kitasato University
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.EBI
Kitasato University
Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.EBI
Kitasato University
Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.EBI
Kitasato University
The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans.EBI
University of Maryland
Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.EBI
Biological Research Center of The Hungarian Academy of Sciences
18F-labeled sufentanil for PET-imaging of mu-opioid receptors.EBI
Technische Universit£T M£Nchen
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.EBI
University of Arizona
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.EBI
Smithkline Beecham
Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.EBI
University of Minnesota
7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.EBI
University of Minnesota
Antipodal alpha-N-(methyl through decyl)-N-normetazocines (5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphans): in vitro and in vivo properties.EBI
Virginia Commonwealth University
Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine.EBI
University of Minnesota
Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity.EBI
Ciba-Geigy
Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.EBI
TBA
Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity.EBI
Merck
 
Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studiesEBI
TBA
Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.EBI
Kitasato University
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).EBI
Kitasato University
Design and synthesis of KNT-127, ad-opioid receptor agonist effective by systemic administration.EBI
Kitasato University
Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans.EBI
University of Debrecen
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.EBI
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.EBI
TBA
Ligand-based prediction of active conformation by 3D-QSAR flexibility descriptors and their application in 3+3D-QSAR models.EBI
University of Szeged
Modulating ?-arrestin 2 recruitment at the ?- and ?-opioid receptors using peptidomimetic ligands.EBI
The Ohio State University
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists.EBI
Virginia Commonwealth University
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment.EBI
Virginia Commonwealth University
Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists.EBI
Johnson and Johnson Pharmaceutical Research and Development
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity.EBI
Virginia Commonwealth University
Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the ?-Opioid Receptor for the Treatment of Chronic Abdominal Pain.EBI
Medical University of Vienna
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.EBI
Biological Research Center of The Hungarian Academy of Sciences
Exploring naltrexamine derivatives featuring azaindole moiety via nitrogen-walk approach to investigate their in vitro pharmacological profiles at the mu opioid receptor.EBI
Virginia Commonwealth University
Isolation and Pharmacological Characterization of Six Opioidergic EBI
University of Illinois At Chicago
Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry.EBI
Virginia Commonwealth University
Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB).EBI
Daiichi Fine Chemical
Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization.EBI
Virginia Commonwealth University
Design and synthesis of a bivalent probe targeting the putative mu opioid receptor and chemokine receptor CXCR4 heterodimer.EBI
Virginia Commonwealth University
Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues.EBI
Virginia Commonwealth University
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ?-Arrestin-2.EBI
Memorial Sloan Kettering Cancer Center
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.EBI
The University of Arizona
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety.EBI
Synaptic Pharmaceutical
Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.EBI
Sapienza University of Rome
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-[(4'-pyridyl)carboxamido]morphinan (NAP) Derivatives as ?/? Opioid Receptor Dual Selective Ligands.EBI
Virginia Commonwealth University
7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.EBI
University of Minnesota
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators.EBI
Virginia Commonwealth University
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.EBI
University of Ferrara
The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, ? opioid receptor agonists.EBI
Kitasato University
N-Alkyl dien- and trienamides from the roots of Otanthus maritimus with binding affinity for opioid and cannabinoid receptors.EBI
Uos of Cagliari
Novel 6?-acylaminomorphinans with analgesic activity.EBI
Semmelweis University
Synthesis and biological evaluation of novel delta (?) opioid receptor ligands with diazatricyclodecane skeletons.EBI
C.N.R. Istituto Di Farmacologia Traslazionale
Structure activity relationship studies of 17-cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affinity and function.EBI
Virginia Commonwealth University
Access to 7?-analogs of codeine with mixed ?/? agonist activity via 6,7-?-epoxide opening.EBI
University of Texas At Austin
Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.EBI
Smithkline Beecham Farmaceutici
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.EBI
Kitasato University
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.EBI
Institute of Materia Medica
Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo.EBI
TBA
Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues.EBI
TBA
?-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.EBI
Vrije Universiteit Brussel
Chemical space screening around PheEBI
Vrije Universiteit Brussel
Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities.EBI
Kitasato University
Naphtho and benzo analogues of the kappa opioid agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide.EBI
University of Notre Dame
Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents.BDB
Hazara University
Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against protein tyrosine phosphatase 1B.BDB
Jiangnan University