PMID

Data

Article Title

Organization

Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.

Amgen

TRPA1 channels as targets for resveratrol and related stilbenoids.

Sapienza University of Rome

a-Aryl pyrrolidine sulfonamides as TRPA1 antagonists.

Genentech

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.

University of Eastern Piedmont

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.

University of Siena

Development of novel azabenzofuran TRPA1 antagonists as in vivo tools.

Amgen

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.

Sapienza University of Rome

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist.

Raqualia Pharma

Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.

Genomics Institute of The Novartis Research Foundation

Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists.

Astrazeneca

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.

Sapienza University of Rome

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.

Sapienza University of Rome

Tetrahydro-ß-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.

Sapienza University of Rome

Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.

Sapienza University of Rome

Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

Ferrara University

New tetrazole-based selective anandamide uptake inhibitors.

Sapienza University of Rome

Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.

Sapienza University of Rome

7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation.

University of Ferrara

Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists.

Janssen Pharmaceutica

Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).

Universita` Del Piemonte Orientale

Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.

Pfizer

(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels.

Sapienza University of Rome

Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens.

Università

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.

Florence University

A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.

Genentech

Structural and in Vitro Functional Characterization of a Menthyl TRPM8 Antagonist Indicates Species-Dependent Regulation.

Marshall University

Cannabitwinol, a Dimeric Phytocannabinoid from Hemp,

University of Naples Federico Ii

Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity.

University of Siena

Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

National Research Council

Cytoprotective effects of hydrogen sulfide-releasing

Harvard Medical School

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space.

University of Naples Federico II

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

University of Eastern Piedmont

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

Pharmaron-Beijing

Discovery of a Series of Indazole TRPA1 Antagonists.

Pfizer