The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.6M data for 1.1M Compounds and 8.9K Targets. Of those, 1,179K data for 544K Compounds and 4.4K Targets were curated by BindingDB curators.

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16 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

Article Title
1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors.EBI
Cephalon Inc
Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.EBI
Boehringer Ingelheim Pharmaceuticals Inc
Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell cultureEBI
Peptidyl epoxides as inhibitors of α-chymotrypsin: Remarkable change from irreversible to reversible competitive inhibitor as a consequence of the improvement of binding affinityEBI
Inactivation of serine protease, α-chymotrypsin by fluorinated phenylalanine analoguesEBI
N-(carbobenzyloxy)isatin: A slow binding α-keto lactam inhibitor of α-chymotrypsinEBI
Inhibition of alpha-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion.EBI
Pohang University of Science and Technology
Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.EBI
3-Dimensional Pharmaceuticals Inc
The discovery of orally available thrombin inhibitors: optimisation of the P1 pharmacophore.EBI
Novartis Horsham Research Centre
Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors.EBI
Nippon Steel Corporation
Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams.EBI
Boehringer Ingelheim (Canada) Ltd
Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids.EBI
ProScript, Inc.
Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.EBI
The University of Queensland
Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsin and elastase.EBI
Enol lactone inhibitors of serine proteases. The effect of regiochemistry on the inactivation behavior of phenyl-substituted (halomethylene)tetra- and -dihydrofuranones and (halomethylene)tetrahydropyranones toward alpha-chymotrypsin: stable acyl enzyme intermediate.EBI
Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.EBI
Merrell Dow Research Institute