PMID

Data

Article Title

Organization

Synthesis and biological activity of 4-(diphenylmethyl)-alpha-[(4-quinolinyloxy)methyl]-1-piperazineethanol and related compounds.

Warner-Lambert

Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3- pyridine-carboxylate and analogues. Synthesis and structure-activity relationships.

Warner-Lambert

Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity.

Suntory Institute For Biomedical Research

2-(2-Aryl-2-oxoethylidene)-1,2,3,4-tetrahydropyridines. Novel isomers of 1,4-dihydropyridine calcium channel blockers.

Warner-Lambert

Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

TBA

Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol.

Pharmacokinetics

Vascular L-type Ca²¿ channel blocking activity of sulfur-containing indole alkaloids from Glycosmis petelotii.

Vietnam Academy of Science and Technology

Selective optimization of side activities: another way for drug discovery.

Prestwick Chemical

Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Fourth Military Medical University

 

Heterocyclic guanidines as calcium antagonists

TBA

 

CGS 27830, a potent nonpeptide endothelin receptor antagonist

TBA

De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.

Synaptic Pharmaceutical

Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA.

Parke-Davis Neuroscience Research Centre

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.

Warner-Lambert

New purines and purine analogs as modulators of multidrug resistance.

Institut De Recherches Servier

Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric).

Seoul National University

Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.

Solvay Duphar

Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels.

Ajinomoto Pharmaceuticals

Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker.

Universita Degli Studi Di Perugia

L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives.

Universita Degli Studi Di Bologna

Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening.

University of Perugia

The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Ajinomoto

Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action.

Universidad De Chile

Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Ajinomoto

Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.

Boehringer Ingelheim Pharma

Vasorelaxation by new hybrid compounds containing dihydropyridine and pinacidil-like moieties.

National Academy of Sciences of Ukraine

Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.

New York University Medical Center

Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiaca.

Shandong University

Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.

Warner-Lambert