PMID

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Article Title

Organization

Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.

Warner-Lambert

Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models.

University of Alabama

Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel.

University of Alabama

2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators.

Institut Henri Beaufour

Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety.

Pharmacia & Upjohn

A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects.

Institute For Bio-Medical Research

Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.

Pharmacia & Upjohn

 

Batrachotoxin binding site antagonists

TBA

The design, preparation and SAR of novel small molecule sodium (Na(+)) channel blockers.

Arqule

Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.

Boehringer Ingelheim Pharma

Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel.

University of Alabama At Birmingham

Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.

Bial

Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel.

University of Alabama At Birmingham

Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations.

Howard University

Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel.

University of Alabama At Birmingham