BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 772K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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6 articles for PH Groot

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Cmpds
Data
Article Title
Organization
4
CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.EBI
Glaxosmithkline
7
Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.EBI
Glaxosmithkline
36
CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.EBI
Smithkline Beecham Pharmaceuticals
34
ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.EBI
Smithkline Beecham Pharmaceuticals
54
ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme.EBI
Smithkline Beecham Pharmaceuticals
13
Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based inhibitors of ATP citrate lyase.EBI
Smithkline Beecham Pharmaceuticals