BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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23 articles for HJ Dyke

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.EBI
Celltech R&D
Synthesis and profile of SCH351591, a novel PDE4 inhibitor.EBI
Schering-Plough
8-Methoxyquinolines as PDE4 inhibitors.EBI
Schering-Plough
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.EBI
Celltech R&D
Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors.EBI
Celltech R&D
7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.EBI
Celltech-Chiroscience
PDE4 inhibitors: new xanthine analogues.EBI
Chiroscience
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.EBI
Argenta Discovery
Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.EBI
Astrazeneca
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.EBI
Argenta Discovery
Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.EBI
Argenta Discovery
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity.EBI
Corcept Therapeutics
2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists.EBI
Corcept Therapeutics
Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.EBI
University of Edinburgh
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators.EBI
Argenta Discovery
Quinazoline and benzimidazole MCH-1R antagonists.EBI
Argenta Discovery
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.EBI
Argenta Discovery
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.EBI
Argenta Discovery
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.EBI
Ucb Pharma
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.EBI
Celltech R and D
A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.EBI
Argenta Discovery
Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists.EBI
Argenta Discovery
Aryl sulfonamides as selective PDE4 inhibitors.EBI
Chiroscience