BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 772K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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7 articles for K Sagawa

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Cmpds
Data
Article Title
Organization
41
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.EBI
Minase Research Institute
10
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.EBI
Ono Pharmaceutical
15
Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.EBI
Ono Pharmaceutical
36
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.EBI
Ono Pharmaceutical
9
Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.EBI
Ono Pharmaceutical
14
Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.EBI
Minase Research Institute
17
Design and synthesis of a highly selective EP2-receptor agonist.EBI
Minase Research Institute