BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 772K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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26 articles for DL Flynn

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Cmpds
Data
Article Title
Organization
13
Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.EBI
Eli Lilly
14
Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.EBI
Pfizer
4
Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.EBI
Pfizer
14
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.EBI
Searle Research and Development
6
 
New aza(nor)adamantanes are agonists at the newly identified serotonin 5-HT4 receptor and antagonists at the 5-HT3 receptorEBI
TBA
21
Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region.EBI
Deciphera Pharmaceuticals
34
Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase.EBI
Pfizer
7
 
Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamidesEBI
TBA
10
 
Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell cultureEBI
TBA
8
 
Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenaseEBI
TBA
9
 
1,3,4-trisubstituted pyrrolidinones as scaffolds for construction of peptidomimetic cholecystokinin antagonistsEBI
TBA
8
Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.EBI
Tufts Medical Center
25
Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.EBI
Deciphera Pharmaceuticals
20
Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT).EBI
Deciphera Pharmaceuticals
2
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.EBI
Pfizer
17
Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.EBI
Warner-Lambert
28
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.EBI
Warner-Lambert
217
SUBSTITUTED PYRROLO[2,1-F][1,2,4]TRIAZIN-2-AMINES AS CDK2 AND CDK4 INHIBITORSBDB
Incyte
28
KV3 modulatorsBDB
Autifony Therapeutics
87
CDK Inhibitors And Their Use As PharmaceuticalsBDB
Prelude Therapeutics
363
INDAZOLE COMPOUNDS AS KINASE INHIBITORSBDB
Tyra Biosciences
5
Inhibitors for the B-catenin/B-cell lymphoma 9 (BCL9) protein-protein interactionBDB
H. Lee Moffitt Cancer Center and Research Institute
38
SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOFBDB
The Broad Institute
148
Granzyme B directed imaging and therapyBDB
Cytosite Biopharma
21
Monoamine oxidase inhibition by C4-substituted phthalonitriles.BDB
North-West University
14
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.BDB
University of Ferrara