BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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14 articles for P Lopez

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aß Reduction without Cardiovascular Liabilities.EBI
Amgen
Development of 2-aminooxazoline 3-azaxanthenes as orally efficaciousß-secretase inhibitors for the potential treatment of Alzheimer's disease.EBI
Amgen
Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.EBI
Eli Lilly
Design and synthesis of potent, orally efficacious hydroxyethylamine derivedß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.EBI
Amgen
Design and preparation of a potent series of hydroxyethylamine containingß-secretase inhibitors that demonstrate robust reduction of centralß-amyloid.EBI
Amgen
A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of ß-Secretase.EBI
TBA
From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).EBI
Amgen
Discovery of a Covalent Inhibitor of KRASEBI
TBA
3-CYCLIC AMINE-INDOLE DERIVATIVES AS SEROTONERGIC AGENTS FOR THE TREATMENT OF CNS DISORDERSBDB
Mindset Pharma
Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenaseBDB
Idorsia Pharmaceuticals
Heterocyclic derivative and pharmaceutical composition comprising the sameBDB
Shionogi
Synthesis of Novel Hybrids Inspired from Bromopyrrole Alkaloids Inhibiting MMP-2 and -12 as Antineoplastic Agents.BDB
University of Kwazulu-Nata
3-substituted-2-(arlyalkyl)-1-azabicycloalkanes and methods of use thereofBDB
Targacept
Interactive binding between the substrate and allosteric sites of carbamoyl-phosphate synthetase.BDB
Pennsylvania State University