Binding Database

BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 765K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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11 articles for JP Mathias

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Cmpds

Data

Article Title

Organization

4

Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.

Pfizer

12

Fragment based discovery of a novel and selective PI3 kinase inhibitor.

Pfizer

14

Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.

Pfizer

33

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.

Pfizer

24

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

Pfizer

51

Macrocyclic indoles as Mcl-1 inhibitors

Ascentage Pharma (Suzhou)

7

Quinoline analogs as phosphatidylinositol 3-kinase inhibitors

Hangzhou Zhengxiang Pharmaceuticals

65

Spirocyclic dihydro-thiazine and dihydro-oxazine BACE inhibitors, and compositions and uses thereof

Imago Pharmaceuticals

7

Effects of novel human cathepsin S inhibitors on cell migration in human cancer cells.

National Tsing Hua University

97

Buprenorphine analogs

Purdue Pharma

87

5-substituted indazoles as kinase inhibitors

Abbvie