BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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22 articles for DC Cole

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).EBI
Takeda California
Identification and characterization of acidic mammalian chitinase inhibitors.EBI
Pfizer
Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.EBI
Wyeth Research
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.EBI
Wyeth Research
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.EBI
Wyeth Research
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase.EBI
Zeneca Pharmaceuticals
Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists.EBI
Wyeth Research
Identification of a new class of small molecule C5a receptor antagonists.EBI
Wyeth Research
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.EBI
Wyeth Research
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.EBI
Wyeth Research
Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters.EBI
Wyeth Research
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.EBI
Wyeth Research
Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists.EBI
Wyeth Research
N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.EBI
Wyeth Research
Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes.EBI
Takeda California
Pyridinone and pyrimidinone derivatives as factor XiaBDB
Ono Pharmaceutical
Inhibitors of RETBDB
Blueprint Medicines
Sulfoximine substituted quinazolines for pharmaceutical compositionsBDB
Evotec International
Inhibitors of lysine specific demethylase-1BDB
Celgene Quanticel Research
Sultam hydroxamates as novel matrix metalloproteinase inhibitors.BDB
Bristol-Myers Squibb
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.BDB
Vernalis (R&D)
6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).BDB
Glaxosmithkline