BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 748K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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25 articles for J Bard

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.EBI
Pfizer
Identification of pyrimidine derivatives as hSMG-1 inhibitors.EBI
Pfizer
Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors.EBI
Wyeth Research
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.EBI
Wyeth Research
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).EBI
Pfizer
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region.EBI
Pfizer
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.EBI
Wyeth
Pyridinyl aminohydantoins as small molecule BACE1 inhibitors.EBI
Wyeth Research
Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).EBI
Wyeth Research
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.EBI
Wyeth Research
Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.EBI
Wyeth Research
Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors.EBI
Wyeth Research
Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.EBI
Wyeth Research
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.EBI
Wyeth Research
Thiophene substituted acylguanidines as BACE1 inhibitors.EBI
Wyeth Research
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.EBI
Wyeth Research
Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.EBI
Wyeth Research
2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereofBDB
Georgetown University
5,5-bicyclic oxazole orexin receptor antagonistsBDB
Merck Sharp & Dohme
Compounds and methods for kinase modulation, and indications thereforBDB
Plexxikon
Inhibitors of lysine specific demethylase-1BDB
Celgene Quanticel Research
Identification of a potent new chemotype for the selective inhibition of PDE4.BDB
Nih
Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor.BDB
Bayer Healthcare
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease.BDB
National Defense Medical Center