151 articles for J Kim
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Identification of lead small molecule inhibitors of glycogen synthase kinase-3 beta using a fragment-linking strategy.
Institute For Basic Science (Ibs)
Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists.
Daegu-Gyeongbuk Medical Innovation Foundation
Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.
Catholic University of Daegu
Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists.
Chung-Ang University
Development and biological evaluation of potent and selective c-KIT(D816V) inhibitors.
Korea Advanced Institute of Science and Technology (Kaist)
Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors.
Institut Pasteur Korea
Lead optimization of a novel series of imidazo[1,2-a]pyridine amides leading to a clinical candidate (Q203) as a multi- and extensively-drug-resistant anti-tuberculosis agent.
Institut Pasteur Korea
The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-a and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.
Korea University
Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.
Institute of Science and Technology
Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL.
Korea Advanced Institute of Science and Technology
3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA).
Kyung Hee University
ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.
Northwestern University
Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities.
Korea Advanced Institute of Science and Technology (Kaist)
Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.
TBA
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
University of Washington
Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners.
Green Cross
Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists.
Reen Cross
In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor.
Kyung Hee University
Discovery of new aminopyrimidine-based phosphoinositide 3-kinase beta (PI3Kß) inhibitors with selectivity over PI3Ka.
Institute of Science and Technology (Kaist)
Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents.
Green Cross
Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.
Green Cross
Novel macrocyclic C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents.
Green Cross
New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity.
Chosun University
Thiazolylmethyl ortho-substituted phenyl glucoside library as novel C-aryl glucoside SGLT2 inhibitors.
Green Cross Corporation Research Center
Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.
Korea Institute of Science and Technology
Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis.
Northwestern University
Synthesis and SAR of Thiazolylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors
TBA
Pyrimidinylmethylphenyl glucoside as novel C-aryl glucoside SGLT2 inhibitors.
Green Cross
Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.
Green Cross
Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist.
Green Cross
Further optimization of novel pyrrole 3-carboxamides for targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.
Green Cross
Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: Pyridazinylmethylphenyl glucoside congeners.
Green Cross
Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.
Green Cross
Synthesis and structure-activity relationship of 1,2,4-triazole-containing diarylpyrazolyl carboxamide as CB1 cannabinoid receptor-ligand.
Green Cross
Silicon switch approach in TRPV1 antagonist MK-056 and its analogues.
Sookmyung Women'S University
Synthesis and PGE(2) production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives.
Kyung Hee University
Synthesis and structure-activity relationship of novel diarylpyrazole imide analogues as CB1 cannabinoid receptor ligands.
Green Cross
Oxadiazole-diarylpyrazole 4-carboxamides as cannabinoid CB1 receptor ligands.
Green Cross
Diarylimidazolyl oxadiazole and thiadiazole derivatives as cannabinoid CB1 receptor antagonists.
Green Cross
Biarylpyrazolyl oxadiazole as potent, selective, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity.
Green Cross
T-type Ca2+ channel blockers suppress the growth of human cancer cells.
Kyung Hee University
Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.
Central Research Institute
Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla.
Seoul National University
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
Seoul National University
Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy.
Gwangju Institute of Science and Technology
Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
Korea University
Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity.
Yeungnam University
Discovery of 2,6-Naphthyridine Analogues as Selective FGFR4 Inhibitors for Hepatocellular Carcinoma.
Sungkyunkwan University
Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease.
Hanyang University
Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects.
Korea Institute of Science and Technology (KIST)
Discovery of BET specific bromodomain inhibitors with a novel scaffold.
University of Science & Technology
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.
Pusan National University
Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.
Biogen Idec
Discovery of Pan-peroxisome Proliferator-Activated Receptor Modulators from an Endolichenic Fungus,
Seoul National University
Synthesis of a red-shifted fluorescence polarization probe for Hsp90.
Memorial Sloan-Kettering Cancer Center
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis.
Korea Institute of Science & Technology (Kist)
Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase.
Keimyung University
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
Memorial Sloan-Kettering Cancer Center
Design and synthesis of endocannabinoid enzyme inhibitors for ocular indications.
Liberty University
Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.
Blueprint Medicines
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Memorial Sloan-Kettering Cancer Center
Discovery of G Protein-Biased Ligands against 5-HT
Korea Institute of Science and Technology
Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors.
State University of New York
Discovery of G Protein-Biased Antagonists against 5-HT
Korea Institute of Science and Technology
Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties.
Chung-Ang University
Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
Novartis Institutes For Biomedical Research
Discovery of orally active indirubin-3'-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemia.
Gwangju Institute of Science and Technology
Design, synthesis and biological evaluation of new bivalent quinazoline analogues as IAP antagonists.
Chung-Ang University
An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Daegu-Gyeongbuk Medical Innovation Foundation
Development of a Polo-like Kinase-1 Polo-Box Domain Inhibitor as a Tumor Growth Suppressor in Mice Models.
Korea Basic Science Institute (Kbsi)
Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor γ (ERRγ) Inverse Agonists.
Daegu-Gyeongbuk Medical Innovation Foundation
2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore.
Seoul National University
Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective.
Daegu-Gyeongbuk Medical Innovation Foundation
Evaluation of anti-depressant effects of phthalazinone-based triple-acting small molecules against 5-HT
Korea Institute of Science and Technology
Application of Fragment-Based de Novo Design to the Discovery of Selective Picomolar Inhibitors of Glycogen Synthase Kinase-3 Beta.
Sejong University
The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3.
Gwangju Institute of Science and Technology (Gist)
Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
Daegu-Gyeongbuk Medical Innovation Foundation
Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla.
Seoul National University
A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions.
Concordia University Wisconsin
Molecular Networking Reveals the Chemical Diversity of Selaginellin Derivatives, Natural Phosphodiesterase-4 Inhibitors from
Seoul National University
Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives.
Yonsei University
Identification of a Unique Resorcylic Acid Lactone Derivative That Targets Both Lymphangiogenesis and Angiogenesis.
Korea University
Design, synthesis, and in vitro evaluation of N-(3-(3-alkyl-1H-pyrazol-5-yl) phenyl)-aryl amide for selective RAF inhibition.
Hanyang University
Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors.
Yonsei University
Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
Korea Institute of Science and Technology
Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors.
Jeil Pharmaceutical
Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant.
Korea Institute of Science and Technology (Kaist)
Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent.
Institut Pasteur Korea
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.
Yale University
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
Seoul National University
Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.
Korea Institute of Science and Technology
Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy.
Seoul National University
C-Methylated Flavonoid Glycosides from Pentarhizidium orientale Rhizomes and Their Inhibitory Effects on the H1N1 Influenza Virus.
Seoul National University
Berchemiosides A-C, 2-Acetoxy-ω-phenylpentaene Fatty Acid Triglycosides from the Unripe Fruits of Berchemia berchemiifolia.
Seoul National University
2-Methylacrylamide as a bioisoster of thiourea group for 1,3-dibenzylthioureido TRPV1 receptor antagonists.
Sookmyung Women'S University
PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation.
Seoul National University
NOVEL COMPOUND AND USE THEREOF FOR INHIBITING CHECKPOINT KINASE 2
Arum Therapeutics
PHENYL AZEPINES AS RIPK1 INHIBITORS AND METHODS OF USE THEREOF
Merck Sharp & Dohme
Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof
Haisco Pharmaceuticals
PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Broadenbio
Methods and compositions of 4-substituted benzoylpiperazine-1-substituted carbonyls as β-catenin/B-cell lymphoma 9 inhibitors
University of Utah
1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
Angelini Acraf
1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor
Shijiazhuang Sagacity New Drug Development
Intermediate compound of novel tetrahydronaphthyl urea derivative
Mochida Pharmaceutical
Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists
King''S College London
Amide compounds as kinase inhibitors, compositions and methods of treatment
Translation Drug Development
Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof
Leo Pharma
Inhibitors of cellular necrosis and related methods
President and Fellows of Harvard College
Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof
Constellation Pharmaceuticals
Synthesis, crystal structure determination, biological screening and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases.
University of Sargodha
Beta-amyloid-directed multitarget compounds for the treatment of alzheimer's disease
Universitat De Barcelona
Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives.
Nirma University
Amidopyrazole inhibitors of interleukin receptor-associated kinases
Merck Sharp & Dohme
Creating an a7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein
Uc San Diego
Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist.
University of North Carolina
Affinity reagents that target a specific inactive form of protein kinases.
University of Washington
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals