BDBM745670 US12319655, Example 150

SMILES CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)n2)ccn1

InChI Key InChIKey=FUMHYHLCMJBSBW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 745670   

TargetSerine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745670(US12319655, Example 150)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [416-766](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745670(US12319655, Example 150)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745670(US12319655, Example 150)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM745670(US12319655, Example 150)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
Go to US Patent