BDBM10297 1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione::Isatin analog 1

SMILES CN1C(=O)C(=O)c2cc(ccc12)N(=O)=O

InChI Key InChIKey=JPTDPTOWOMFBRY-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 10297   

TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10297(1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  500nM ΔG°:  -8.73kcal/mole IC50:  1.00E+3nMpH: 7.5 T: 30°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed