BDBM103302 SCH772984::US8546404, 6
SMILES O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1
InChI Key InChIKey=HDAJDNHIBCDLQF-RUZDIDTESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 103302
Affinity DataIC50: 0.800nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair
Affinity DataKd: 300nMpH: 7.5 T: 2°CAssay Description:For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 632nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 114nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 783nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 3(Homo sapiens (Human))
George Washington University
George Washington University
Affinity DataIC50: 304nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 580nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 104nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 508nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin [465-798](Homo sapiens (Human))
George Washington University
George Washington University
Affinity DataIC50: 398nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 193nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 942nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
George Washington University
George Washington University
Affinity DataIC50: 503nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataIC50: 535nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Affinity DataKd: 213nMpH: 7.5 T: 2°CAssay Description:For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...More data for this Ligand-Target Pair
Affinity DataKd: 233nMpH: 7.5 T: 2°CAssay Description:For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin [465-798](Homo sapiens (Human))
George Washington University
George Washington University
Affinity DataKd: 297nMpH: 7.5 T: 2°CAssay Description:For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...More data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 4 hits for monomerid = 103302
ITC DataΔG°: -8.78kcal/mole −TΔS°: 11.8kcal/mole ΔH°: -20.6kcal/mole logk: 4.59E+6
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C
ITC DataΔG°: -8.70kcal/mole −TΔS°: 12.4kcal/mole ΔH°: -21.1kcal/mole logk: 4.02E+6
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C
ITC DataΔG°: -8.66kcal/mole −TΔS°: 8.95kcal/mole ΔH°: -17.6kcal/mole logk: 3.71E+6
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C
ITC DataΔG°: -9.08kcal/mole −TΔS°: 21.5kcal/mole ΔH°: -30.6kcal/mole logk: 3.57E+6
pH: 7.5 T: 30.00°C
pH: 7.5 T: 30.00°C