BDBM103727 US10112907, Example 00033::US10206907, Compound 200::US10708263, Compound 1::US10766894, Compound TABLE 1.18::US10919890, Compound 1::US10961228, Example Filgotinib::US11000528, Cpd # 1::US11203595, TABLE 1.18::US11279699, Compound Filgotinib::US8563545, 1

SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1

InChI Key InChIKey=RIJLVEAXPNLDTC-UHFFFAOYSA-N

Data  102 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 103727   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  47.1nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  55.7nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  50.1nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  48.3nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  31.4nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  41.2nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  55.5nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  167nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  149nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  187nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  189nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  195nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  72.7nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  73.8nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  79.1nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  86.8nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent