BDBM10755 14C-5-hydroxy tryptamine creatinine disulfate::2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid)::5-HT::5-Hydroxy Tryptamine::5-hydroxy tryptamine creatinine disulfate::CHEMBL535832::Serotonin::[3H]-5-HT
SMILES NCCc1c[nH]c2ccc(O)cc12
InChI Key InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 74 hits for monomerid = 10755
Affinity DataIC50: 28nMAssay Description:Antagonist activity at recombinant human 5-HT2A expressed in human U2OS cells by pathhunter beta-arrestin assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at recombinant human 5-HT2C expressed in human U2OS cells by pathhunter beta-arrestin assayMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibition of MIF tautomerase (unknown origin) using 4-HPP as substrate preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
TargetMAP/microtubule affinity-regulating kinase 4(Homo sapiens (Human))
Jamia Millia Islamia
Curated by ChEMBL
Jamia Millia Islamia
Curated by ChEMBL
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of MARK4 (unknown origin) ATPase activity using ATP as substrate incubated for 1.5 hr in presence of MgCl2 by Biomol green reagent based E...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 2 receptor using [3H]ket as radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Effect of the compound on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.More data for this Ligand-Target Pair
3D Structure (crystal)Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University Of Alberta
Curated by PDSP Ki Database
University Of Alberta
Curated by PDSP Ki Database
Affinity DataIC50: 4.90nMAssay Description:Displacement of [125I]CYP from rat cerebral cortex 5HT1B receptor measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT5A receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University Collegium Medicum
Curated by ChEMBL
Jagiellonian University Collegium Medicum
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University Collegium Medicum
Curated by ChEMBL
Jagiellonian University Collegium Medicum
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT5a receptor in HEK293 cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Displacement of [3H]-ketanserin from 5HT2A receptor in rat brain cortical membranes after 15 mins by competition assay in presence of Gpp(NH)pMore data for this Ligand-Target Pair
Affinity DataIC50: 3.06E+4nMAssay Description:Displacement of [3H]-ketanserin from 5HT2A receptor low affinity component in rat brain cortical membranes after 15 mins by competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Displacement of [3H]-ketanserin from 5HT2A receptor high affinity component in rat brain cortical membranes after 15 mins by competition assayMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 3(Rattus norvegicus)
Medical College Of Georgia
Curated by ChEMBL
Medical College Of Georgia
Curated by ChEMBL
Affinity DataIC50: 9.70E+4nMAssay Description:TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in OCT3-expressing HRPE cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 min before substrate addition and ...More data for this Ligand-Target Pair
Affinity DataIC50: 323nMAssay Description:Displacement of [3H]-GR 113808 from recombinant human brain 5HT4 receptor measured after 60 mins by radio ligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University Collegium Medicum
Curated by ChEMBL
Jagiellonian University Collegium Medicum
Curated by ChEMBL
Affinity DataIC50: 27.5nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor by scintillation countingMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Universit£T Leipzig
Curated by ChEMBL
Universit£T Leipzig
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£T Leipzig
Curated by ChEMBL
Universit£T Leipzig
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EGFR after 30 mins by chemiluminescence ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.01E+5nMAssay Description:Inhibition of Candida albicans isocitrate lyaseMore data for this Ligand-Target Pair
Affinity DataIC50: >3.50E+5nMAssay Description:Inhibition of mushroom tyrosinase after 25 mins by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 0nMAssay Description:Agonist required to inhibit Dopamine receptor D2 photoinactivation by 50% with Iodazidoclebopride using [3H]-SpiperoneMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Emory University
Curated by PDSP Ki Database
Emory University
Curated by PDSP Ki Database
Affinity DataIC50: 2.60nMAssay Description:Inhibition of radiolabeled [3H]-8-OH-DPAT ligand binding to 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 147nMAssay Description:Inhibition of radiolabeled [3H]GR-113808 ligand binding to 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.35E+3nMAssay Description:Inhibition of radiolabeled [3H]-Ketanserin ligand binding to 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 727nMAssay Description:Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
University Of Alberta
Curated by PDSP Ki Database
University Of Alberta
Curated by PDSP Ki Database
Affinity DataIC50: 42nMAssay Description:Inhibition of radiolabeled [3H]mesulergine ligand binding to 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University Of Alberta
Curated by PDSP Ki Database
University Of Alberta
Curated by PDSP Ki Database
Affinity DataIC50: 4.60nMAssay Description:Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Alberta
Curated by PDSP Ki Database
University Of Alberta
Curated by PDSP Ki Database
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Compound was tested for the displacement of [3H]-5-HT to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.01E+5nMAssay Description:Inhibition of Candida albicans isocitrate lyaseMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A/2B/2C(Mus musculus (Mouse))
Polytechnic University
Curated by ChEMBL
Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 680nMAssay Description:Inhibitory activity towards 5-hydroxytryptamine 2 receptor by the displacement of [3H]ketanserin in mouse cerebral cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of radioligand [3H]5-HT binding to 5-hydroxytryptamine 1D receptor in pig caudate membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Binding activity against 5-hydroxytryptamine 1D receptor from pig caudate membrane using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 2 receptor of rat anterior cortex using [3H]ketanserin as the radiolig...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Alberta
Curated by PDSP Ki Database
University Of Alberta
Curated by PDSP Ki Database
Affinity DataIC50: 6nMAssay Description:Compound was tested in vitro for the inhibition of [3H]-5-HT (2 nM) binding to 5-hydroxytryptamine 1A receptor from bovine hippocampusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Alberta
Curated by PDSP Ki Database
University Of Alberta
Curated by PDSP Ki Database
Affinity DataIC50: 5.60nMAssay Description:Compound was tested in vitro for the inhibition of [125I]-IPAPP (0.25 nM) binding to 5-HT1A receptor from bovine hippocampusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Alberta
Curated by PDSP Ki Database
University Of Alberta
Curated by PDSP Ki Database
Affinity DataIC50: 2nMAssay Description:Compound was tested in vitro for the inhibition of [3H]-DPAT (1 nM) binding to 5-hydroxytryptamine 1A receptor from bovine hippocampusMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibition of COX1 after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibition of COX2 after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Binding affinity of the compound against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
University Of Illinois At Chicago
University Of Illinois At Chicago
Affinity DataIC50: 5.39E+4nMpH: 8.0 T: 2°CAssay Description:The activity of recombinant human QR2 under steady-state conditions was evaluated on a MolecularDevices SpectraMax Plus 384 UV-visible spectrophotome...More data for this Ligand-Target Pair