BDBM112606 US8618103, I-102

SMILES CS(=O)(=O)N1CCC[C@@H](C1)Nc1nc(ncc1-c1cnc2[nH]ccc2n1)N1CC(C1)C#N

InChI Key InChIKey=GQAYABNMBBTJFN-AWEZNQCLSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112606   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM112606(US8618103, I-102)
Affinity DataKi:  0.00625nM IC50:  0.0125nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM112606(US8618103, I-102)
Affinity DataIC50:  0.0485nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent