BDBM116257 US10035794, Example 34::US10683287, Example 34::US8637508, 34

SMILES C[C@]1(CO[C@@](C(=N1)N)(C)C(F)(F)F)c2c(ccc(n2)NC(=O)c3c(cc(cn3)C(F)(F)F)Cl)F

InChI Key InChIKey=PSBBWFNMHDUTRH-UHFFFAOYSA-N

Data  27 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 116257   

TargetBeta-secretase 1(Chinese hamster)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 116257BDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 in CHO cells expressing human APP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 24 hrs by immunoass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116257BDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 7nMAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116257BDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116257BDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116257BDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116257BDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116257BDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)