BDBM119448 US8686018, 107

SMILES C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)(F)F)C(F)F)c1ccc(cc1)C(O)=O

InChI Key InChIKey=MKLKAQMPKHNQPR-NSHDSACASA-N

Data  1 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 119448   

TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eisai R&D Management Co., Ltd

US Patent
LigandPNGBDBM119448(US8686018, 107)
Affinity DataKi:  8nMpH: 7.4Assay Description:The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human EP3 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human EP1 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human EP2 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eisai R&D Management Co., Ltd

US Patent
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity at human EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mus musculus (Mouse))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50:  101nMAssay Description:Antagonist activity at mouse EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human EP1 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human EP2 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human EP3 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eisai R&D Management Co., Ltd

US Patent
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at human EP4 receptor overexpressed in HEK293 cells assessed as reduction in PGE2-mediated cAMP accumulation preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eisai R&D Management Co., Ltd

US Patent
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity at human EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Mus musculus (Mouse))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM119448(US8686018, 107)
Affinity DataIC50:  181nMAssay Description:Antagonist activity at mouse EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed