BDBM120698 Roche-Dataset for PDE10A, Compound 927::US8703768, 299

SMILES CNC(=O)c1c(F)cc(F)cc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1

InChI Key InChIKey=FUMPSJVWIWRSNX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 120698   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM120698(Roche-Dataset for PDE10A, Compound 927 | US8703768...)
Affinity DataIC50:  0.320nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM120698(Roche-Dataset for PDE10A, Compound 927 | US8703768...)
Affinity DataIC50:  0.300nMAssay Description:PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...More data for this Ligand-Target Pair
In DepthDetails US Patent