BDBM123557 US8748624, 43

SMILES Cc1cc(ccc1-c1ccc(NCc2ccc(cc2-c2ccc(nc2)C(=O)NCCC(O)=O)C(F)(F)F)cc1Cl)C(F)(F)F

InChI Key InChIKey=GPKUFXAKPUJEDG-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 123557   

TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM123557(US8748624, 43)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]-glucagon from full length human glucagon receptor expressed in HEK293 cell membranes after 2 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM123557(US8748624, 43)
Affinity DataKi:  17.2nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM123557(US8748624, 43)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human glucagon receptor expressed in HEK293 cell membranes assessed as inhibition of glucagon-stimulated intracellular cAMP fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed