BDBM13058 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate::667-COUMATE::667COUMATE::BN83495::CHEMBL286738::CMT::STX64::{9-oxo-8-oxatricyclo[8.5.0.0^{2,7}]pentadeca-1(10),2(7),3,5-tetraen-5-yl} sulfamate

SMILES c1cc2c(cc1OS(=O)(=O)N)OC(=O)C3=C2CCCCC3

InChI Key InChIKey=DSLPMJSGSBLWRE-UHFFFAOYSA-N

Data  12 KI  31 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 13058   

TargetSteryl-sulfatase(Human)
University of Sharjah

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13058BDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Sharjah

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13058BDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of STS in human JEG-3 cells assessed as inhibition of estrone E1 formation using [3H]estrone sulfate as substrate incubated for 20 hrs in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSteryl-sulfatase(Human)
University of Sharjah

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13058BDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Sharjah

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13058BDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of STS in human JEG-3 cell lysates assessed as inhibition of estrone E1 formation using [3H]estrone sulfate as substrate incubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSteryl-sulfatase(Human)
University of Sharjah

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13058BDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50: 421nMAssay Description:Inhibition of steroid sulfatase in human JEG-3 cells assessed as [14C]-Estrone formation using [3H]E1S as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed