BDBM13519 (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one::(R,R)::1,4-diazepan-2-one 2b::Diazepanone Analog 18

SMILES C[C@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=SWKGZJAAGSVROJ-MWLCHTKSSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 13519   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13519((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Affinity DataIC50:  6.60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13519((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Affinity DataIC50:  5.90E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13519((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Affinity DataIC50:  4.60E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13519((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Affinity DataIC50:  6.60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13519((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Affinity DataIC50:  5.90E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13519((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Affinity DataIC50:  4.60E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed