BDBM14777 (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione::(6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione::CHEMBL779::Cialis::GF 196960::Tadalafil

SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1

InChI Key InChIKey=WOXKDUGGOYFFRN-IIBYNOLFSA-N

Data  4 KI  89 IC50  1 Kd  3 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14777   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant PDE3B-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant PDE3B-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant PDE4B-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed