BDBM14842 1-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-3-(2-phenyl-2H-pyrazol-3-yl)-urea::1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}-3-(1-phenyl-1H-pyrazol-5-yl)urea::BIRB-796 Analog 31::CHEMBL104119::Dopamine D2 receptor and serotonin 2a receptor::diaryl urea compound 1

SMILES O=C(Nc1ccnn1-c1ccccc1)Nc1ccc(OCCN2CCOCC2)c2ccccc12

InChI Key InChIKey=CCSCCHWFDTVWIO-UHFFFAOYSA-N

Data  2 Kd  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14842   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14842(1-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-3-...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14842(1-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-3-...)
Affinity DataKd:  2.40E+3nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 14842   

CellPNGBDBM14842(1-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-3-...)
Boehringer Ingelheim Pharmaceuticals

Syringe5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
ITC DataΔH°: -4.29kcal/mole logk: 8.47E+5
pH: 7.0 T: 25.00°C