BDBM14968 N-Methyl-5-(2-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)ethynyl)picolinamide::N-methyl-5-[2-(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)ethynyl]pyridine-2-carboxamide::heterocyclic akynyl amide 13c

SMILES CNC(=O)c1ccc(cn1)C#Cc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=ZMHVJFIIASNLTM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14968   

TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM14968(N-Methyl-5-(2-(2-methyl-5-((3-(trifluoromethyl)phe...)
Affinity DataIC50:  623nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck [245-498](Homo sapiens (Human))
Amgen

LigandPNGBDBM14968(N-Methyl-5-(2-(2-methyl-5-((3-(trifluoromethyl)phe...)
Affinity DataIC50:  154nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM14968(N-Methyl-5-(2-(2-methyl-5-((3-(trifluoromethyl)phe...)
Affinity DataIC50:  169nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed