BDBM152692 Thiol-SAHA (t-SAHA)

SMILES SCCCCCCC(=O)Nc1ccccc1

InChI Key InChIKey=CFKBMXXDXYFDET-UHFFFAOYSA-N

Data  15 IC50  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 152692   

TargetHistone deacetylase(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 210nMAssay Description:In vitro inhibitory activity against human histone deacetylase (HDAC) using HeLa nuclear extractMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2018
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 19nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using fluorogenic tetrapeptide RHK(Ac)K(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 288nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 201nMAssay Description:Inhibition of HDAC3 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 270nMAssay Description:Inhibition of HDAC10 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 262nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 218nMAssay Description:Inhibition of recombinant human HDAC1 using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 210nMAssay Description:Inhibitory concentration against human histone deacetylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Ghent University

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 210nMAssay Description:Inhibition of HDAC in human HeLa nuclear extractMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC1 in human HeLa nuclear extractMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
R&D Sigma-Tau Industrie Farmaceutiche Riunite

Curated by ChEMBL
LigandPNGBDBM152692(Thiol-SAHA (t-SAHA))
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC2 in human HeLa nuclear extractMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 152692   

CellHistone deacetylase 8 (HDAC8)(Human)
North Dakota State University

SyringePNGBDBM152692(Thiol-SAHA (t-SAHA))
ITC DataΔG°: -7.40kcal/mole −TΔS°: -0.251kcal/mole ΔH°: -4.51kcal/mole logk: 4.17E+5
pH: 7.5 T: -248.15°C