BDBM15384 8-(2,5-dimethoxybenzyl)-2-fluoro-9-pent-4-ynyl-9H-purin-6-amine::8-[(2,5-dimethoxyphenyl)methyl]-2-fluoro-9-(pent-4-yn-1-yl)-9H-purin-6-amine::CHEMBL326082::PUZ::Purine-Based Inhibitor 11

SMILES COc1ccc(OC)c(Cc2nc3c(N)nc(F)nc3n2CCCC#C)c1

InChI Key InChIKey=RMOYVWKKOKERSW-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15384   

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Ribotargets

Curated by ChEMBL
LigandPNGBDBM15384(8-(2,5-dimethoxybenzyl)-2-fluoro-9-pent-4-ynyl-9H-...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of ATP-ase activity in human colon tumour cell line (HCT116)More data for this Ligand-Target Pair
TargetATP-dependent molecular chaperone HSP82(Baker's yeast)
Vernalis (R&D)

LigandPNGBDBM15384(8-(2,5-dimethoxybenzyl)-2-fluoro-9-pent-4-ynyl-9H-...)
Affinity DataIC50:  4.10E+3nMpH: 7.4 T: 37°CAssay Description:The HSP90 ATPase activity was determined by following the procedure of malachite green assay. The assay is based on quantitation of the green complex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed