BDBM164112 US9062078, 242::US9475819, 242::US9637496, 242::US9695183, 242

SMILES COc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1

InChI Key InChIKey=BFRKOXFSGJNCQG-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 164112   

TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164112(US9062078, 242 | US9475819, 242 | US9637496, 242 |...)
Affinity DataKi:  31nM ΔG°:  -9.52kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164112(US9062078, 242 | US9475819, 242 | US9637496, 242 |...)
Affinity DataKi:  41nM ΔG°:  -9.36kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164112(US9062078, 242 | US9475819, 242 | US9637496, 242 |...)
Affinity DataKi:  239nM ΔG°:  -9.48kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In DepthDetails US Patent