BDBM175170 US9115117, 94::US9611251, 94

SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F

InChI Key InChIKey=GJNMWMFMBLUHOI-DZGCQCFKSA-N

Data  6 KI

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 175170   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175170(US9115117, 94 | US9611251, 94)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N8O/c1-12-8-16(31-27-5-6-28-31)17(24-9-12)18(32)30-7-3-4-15(13(30)2)29-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,15H,3-4,7H2,1-2H3,(H,25,26,29)/t13-,15+/m0/s1
Affinity DataKi:  25nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175170(US9115117, 94 | US9611251, 94)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N8O/c1-12-8-16(31-27-5-6-28-31)17(24-9-12)18(32)30-7-3-4-15(13(30)2)29-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,15H,3-4,7H2,1-2H3,(H,25,26,29)/t13-,15+/m0/s1
Affinity DataKi:  25nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor(Genebank accession number NM_001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175170(US9115117, 94 | US9611251, 94)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N8O/c1-12-8-16(31-27-5-6-28-31)17(24-9-12)18(32)30-7-3-4-15(13(30)2)29-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,15H,3-4,7H2,1-2H3,(H,25,26,29)/t13-,15+/m0/s1
Affinity DataKi:  38nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor(Genebank accession number NM_001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica NV

US Patent
LigandPNGBDBM175170(US9115117, 94 | US9611251, 94)
Show SMILES C[C@H]1[C@@H](CCCN1C(=O)c1ncc(C)cc1-n1nccn1)Nc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N8O/c1-12-8-16(31-27-5-6-28-31)17(24-9-12)18(32)30-7-3-4-15(13(30)2)29-19-25-10-14(11-26-19)20(21,22)23/h5-6,8-11,13,15H,3-4,7H2,1-2H3,(H,25,26,29)/t13-,15+/m0/s1
Affinity DataKi:  38nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair