BDBM179867 US11147820, Compound Metopimazine::US9132134, Metopimazine (NG101)

SMILES CS(=O)(=O)c1ccc2Sc3ccccc3N(CCCN3CCC(CC3)C(O)=N)c2c1

InChI Key InChIKey=BQDBKDMTIJBJLA-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 179867   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  0.0700nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  0.610nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  1.5nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  1.90nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  8.40nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataIC50:  2.20nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In DepthDetails US Patent