BDBM19130 (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide::CHEMBL99::TSA::Trichostatin A (TSA)
SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C
InChI Key InChIKey=ALCVRKZFLFWUAZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 19130
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 0.130nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Inhibition of recombinant HDAC1More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 0.260nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Inhibition of recombinant HDAC3More data for this Ligand-Target Pair
Affinity DataKi: 0.760nMAssay Description:Inhibition of recombinant HDAC2More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 0.990nMAssay Description:Inhibition of recombinant HDAC6More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Inhibition of recombinant HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University Of G£Ttingen
Curated by ChEMBL
University Of G£Ttingen
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Displacement of Atto700-HA from Bordetella/Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 19130
ITC DataΔG°: -8.60kcal/mole −TΔS°: 0.214kcal/mole ΔH°: -8.84kcal/mole logk: 2.03E+6
T: 25.00°C
T: 25.00°C