BDBM19502 (2R)-N-(1-cyanocyclopropyl)-3-(cyclopropylmethane)sulfonyl-2-{[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino}propanamide::trifluoroethylamine inhibitor, 12
SMILES Fc1ccc(cc1)[C@H](N[C@@H](CS(=O)(=O)CC1CC1)C(=O)NC1(CC1)C#N)C(F)(F)F
InChI Key InChIKey=NOTSCKFHTQJLMM-HOTGVXAUSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 19502
Affinity DataIC50: 0.5nMpH: 6.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of cathepsin S-mediated antigen presentation in B/T hybridoma cells assessed as IL-2 levelMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of cathepsin L using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 188nMAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair