BDBM20925 5-(5-tert-butyl-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(piperidin-1-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide::Isoxazole, 41g::US10413550, Example 77c::US11234987, Example 77c::US9718793, 77c

SMILES CCNC(=O)c1noc(c1-c1ccc(CN2CCCCC2)cc1)-c1cc(c(O)cc1O)C(C)(C)C

InChI Key InChIKey=COBVQNNJVURGON-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 20925   

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM20925(5-(5-tert-butyl-2,4-dihydroxyphenyl)-N-ethyl-4-[4-...)
Affinity DataIC50: 11nM EC50:  65nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
The Institute of Cancer Research

US Patent
LigandPNGBDBM20925(5-(5-tert-butyl-2,4-dihydroxyphenyl)-N-ethyl-4-[4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Chemicals are of the highest purity commercially available and all aqueous solutions are made up in AR water. Because of the need to minimise contami...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
Go to US Patent

LigandPNGBDBM20925(5-(5-tert-butyl-2,4-dihydroxyphenyl)-N-ethyl-4-[4-...)
Affinity DataIC50: 1.00E+4nMAssay Description: (1) Greiner 384-well (Greiner 781101) or Costar 384-well flat-bottomed polystyrene multiwell plates (VWR). (2) Assay buffer of (a) 100 mM Tris-HCl, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetATP-dependent molecular chaperone HSP82(Baker's yeast)
Cancer Research Technology

US Patent
LigandPNGBDBM20925(5-(5-tert-butyl-2,4-dihydroxyphenyl)-N-ethyl-4-[4-...)
Affinity DataIC50: 5.00E+4nMAssay Description:1. Dilute test compounds to 500 uM in AR water (DMSO concentration will be 2.5%). Transfer 2.5 ul of these compounds directly from the daughter plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent