BDBM21278 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::Acomplia::CHEMBL111::CHEMBL558598::RIMONABANT HYDROCHLORIDE::Rimonabant::SR 141716A::SR141716::SR141716A::[3H]Rimonabant::[3H]SR141716A

SMILES Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1

InChI Key InChIKey=JZCPYUJPEARBJL-UHFFFAOYSA-N

Data  157 KI  80 IC50  10 Kd  24 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 270 hits for monomerid = 21278   

TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 11.2nMAssay Description:Antagonist activity against human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  2.10nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1 [I218A](Human)
North Carolina Central University

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  2.5nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1 [H219A](Human)
North Carolina Central University

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  2.5nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1 [P221A](Human)
North Carolina Central University

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  3.80nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1 [D338A](Human)
North Carolina Central University

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  2.5nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1 [I339A](Human)
North Carolina Central University

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  3.80nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1 [R340A](Human)
North Carolina Central University

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  2.40nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1 [I341A](Human)
North Carolina Central University

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  4.40nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1 [T344A](Human)
North Carolina Central University

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  2.40nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Chinese hamster)
Nanchang University School of Pharmaceutical Science

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 4.72nMAssay Description:The target compounds were evaluated using a binding assay towards the CB1 receptor expressed on the membranes of Chinese hamster ovarian (CHO) cells....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataEC50:  50nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in Sf9 cells coexpressing Gbeta1gamma2 and RSG4 assessed as degradation of [gamma-33P]GTP af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataEC50:  50nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in Sf9 cells coexpressing Gbeta1gamma2 and RSG4 assessed as degradation of [gamma-33P]GTP af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 6.20nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against human recombinant cannabinoid receptor type 1 expressed in Chinese Hamster Ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 9.80E+3nMAssay Description:Antagonist activity at CB2 receptor (unknown origin) expressed in CHO cells up to 10 uM incubated for 10 mins prior to CP55940 addition by calcium mo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at CB1 receptor (unknown origin) expressed in CHO cells up to 10 uM incubated for 10 mins prior to CP55940 addition by calcium mo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity against CB1R (unknown origin) CHO cells stably expressing Galpha16 assessed as inhibition of CP55940-induced increase in intracel...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 9.10E+3nMAssay Description:Antagonist activity against CB2R (unknown origin) CHO cells stably expressing Galpha16 assessed as inhibition of CP55940-induced increase in intracel...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]SR-141716 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 603nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 6.10nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 3.92E+3nMAssay Description:Displacement of [3H]SR141716A from CB1 receptor in Sprague-Dawley rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebella membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHOK1 cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataEC50:  0.170nMAssay Description:Displacement of [3H]SR141716 from Long-Evans rat striatal membrane CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 2.20nMAssay Description:Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 4.57E+3nMAssay Description:Binding affinity to human CB2 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.94E+3nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataEC50:  18.2nMAssay Description:Antagonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHOK1 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 4.53nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP-55940 from cannabinoid CB1 receptor in Sprague-Dawley rat cerebellar membrane by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.76E+3nMAssay Description:Displacement of [3H]WIN-55212-2 from human recombinant cannabinoid CB2 receptor expressed in CHOK1 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 5.20nMAssay Description:Displacement of [3H]WIN-55212-2 from CB1 receptor in rat cerebellar membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataEC50:  18.2nMAssay Description:Antagonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataEC50:  5nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO cells assessed as increase in intracellular calcium mobilization after 90 secs by Cal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Rat)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP-55940 from CB1R in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataEC50:  3.12E+4nMAssay Description:Antagonist activity at human cannabinoid CB2 receptor expressed in CHOK1 cells assessed as cAMP activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataEC50:  240nMAssay Description:Antagonist activity at human cannabinoid CB1 receptor expressed in CHOK1 cells assessed as cAMP activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 13.2nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 1.63E+3nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB2R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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