BDBM22167 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine::CHEMBL26320::CHEMBL434080::GBR 12935::GBR-12935
SMILES C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1
InChI Key InChIKey=RAQPOZGWANIDQT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 44 hits for monomerid = 22167
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataKi: 3.70nMAssay Description:Binding affinity for dopamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataKi: 3.70nMAssay Description:Binding affinity of the compound towards dopamine transporter (DAT)More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataKi: 3.70nMAssay Description:Binding affinity against Dopamine transporter using [125]RTI-55More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataKi: 3.70nMAssay Description:Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataKi: 3.70nMAssay Description:Binding affinity for dopamine transporter (DAT)More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataKi: 3.70nM ΔG°: -10.7kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataKi: 13nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 73nMAssay Description:Inhibition of [125I]RTI-55 binding to dopamine transporterMore data for this Ligand-Target Pair
Affinity DataKi: 620nM ΔG°: -7.87kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
Affinity DataKi: 620nMAssay Description:Binding affinity against serotonin transporter using [125]RTI-55More data for this Ligand-Target Pair
Affinity DataKi: 620nMAssay Description:Binding affinity for serotonin transporterMore data for this Ligand-Target Pair
Affinity DataKi: 623nMAssay Description:Binding affinity against Serotonin transporter (SERT) labelled with [125I]-RTI-55 in rat.More data for this Ligand-Target Pair
Affinity DataKi: 623nMAssay Description:Binding affinity towards rat serotonin transporter (SERT)More data for this Ligand-Target Pair
Affinity DataKi: 623nMAssay Description:Binding affinity for serotonin transporter (SERT)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 630nMAssay Description:Binding affinity at the norepinephrine transporter was measured using [125I]RTI-55 as a radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 2.09E+3nMAssay Description:Binding affinity for serotonin transporter using [125I]RTI-55More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(MOUSE)
National Institutes Of Health
Curated by PDSP Ki Database
National Institutes Of Health
Curated by PDSP Ki Database
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataIC50: 3.70nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataIC50: 37nMAssay Description:Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 623nMAssay Description:Binding affinity was determined at the Serotonin transporter labeled with radioligand [125 I] RTI-55More data for this Ligand-Target Pair
Affinity DataIC50: 289nMAssay Description:Inhibition of [3H]5-HT reuptake at rat serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataIC50: 3.70nMAssay Description:Inhibition of dopamine DA reuptakeMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 3.71E+3nMAssay Description:Inhibition of [3H]5-HT reuptake in HEK293 cells expressing human serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of [3H]dopamine reuptake in HEK293 cells expressing human dopamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 165nMAssay Description:Inhibition of [3H]NE reuptake by human norepinephrine transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataIC50: 4.10nMAssay Description:Binding against Dopamine transporter using radioligand as [3H]GBR 12935More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataIC50: 3.70nMAssay Description:Compound was tested for its ability to inhibit the uptake of [3H]-dopamine in DAT (dopamine transporter system) expressing cell lineMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 289nMAssay Description:Compound was tested for its ability to inhibit the uptake of Serotonin in Serotonin transporter systemMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataIC50: 298nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataIC50: 3.70nMAssay Description:Binding affinity at the dopamine transporter using [125I]-RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Sigma receptor binding was determined by labeling with radioligand [3H]-(+)-pentazocine on frozen membranes obtained from frozen guinea pig brainMore data for this Ligand-Target Pair
Affinity DataIC50: 298nMAssay Description:Reuptake inhibition of [3H]-5-HT (5-HT) in rat.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wake Forest University
Curated by PDSP Ki Database
Wake Forest University
Curated by PDSP Ki Database
Affinity DataIC50: 3.70nMAssay Description:Reuptake inhibition of [3H]-labeled dopamine (DA) in rat.More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1.26E+3nMAssay Description:Compound was tested for its ability to inhibit the uptake of Norepinephrine in Norepinephrine transporter systemMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Compound was tested for its ability to inhibit the neurotransmitter serotonin-5-HT reuptake system using [3H]5-HT as radioligandMore data for this Ligand-Target Pair