BDBM22369 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one::CHEMBL122::MK 0966::Rofecoxib::US11478464, Compound Rofecoxib::US11786535, Compound Rofecoxib

SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1

InChI Key InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N

Data  26 KI  168 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22369   

TargetProstaglandin G/H synthase 2(Bos taurus)
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  430nMAssay Description:In vitro inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50: >5.00E+5nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed