BDBM225230 EED226::US11013745, Compound EED226

SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12

InChI Key InChIKey=DYIRSNMPIZZNBK-UHFFFAOYSA-N

Data  87 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 225230   

TargetPolycomb protein EED(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  82nMpH: 8.0 T: 2°CAssay Description:ITC experiments were performed by Auto ITC200 (Microcal) at 25 °C. ITC sample cell was filled with 10 μM PRC2 in titration buffer (25 mM HEPES p...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12 [559-739](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  114nMpH: 8.0 T: 2°CAssay Description:ITC experiments were performed by Auto ITC200 (Microcal) at 25 °C. ITC sample cell was filled with 10 μM PRC2 in titration buffer (25 mM HEPES p...More data for this Ligand-Target Pair
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  82nMAssay Description:Binding affinity to EED (unknown origin) by ITC methodMore data for this Ligand-Target Pair