BDBM22868 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine::2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaene::Azatadine::CHEMBL946

SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]-[#6]-c2cccnc-12

InChI Key InChIKey=SEBMTIQKRHYNIT-UHFFFAOYSA-N

Data  2 KI  1 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22868   

TargetHistamine H1 receptor(RAT)
Schering-Plough Corporation

Curated by ChEMBL
LigandPNGBDBM22868(11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-b...)
Show SMILES CN1CCC(CC1)=C1c2ccccc2CCc2cccnc12
Show InChI InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3
Affinity DataKi:  3.90nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

LigandPNGBDBM22868(11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-b...)
Show SMILES CN1CCC(CC1)=C1c2ccccc2CCc2cccnc12
Show InChI InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3
Affinity DataKi: >1.00E+4nM ΔG°: >-7.09kcal/molepH: 7.4 T: 2°CAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Schering-Plough Corporation

Curated by ChEMBL
LigandPNGBDBM22868(11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-b...)
Show SMILES CN1CCC(CC1)=C1c2ccccc2CCc2cccnc12
Show InChI InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3
Affinity DataIC50: 5.00E+4nMAssay Description:Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when ch...More data for this Ligand-Target Pair