BDBM23165 CHEMBL366208::FTY720-phosphate, (S)-2::[(2S)-2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy]phosphonic acid
SMILES CCCCCCCCc1ccc(CC[C@](N)(CO)COP(O)(O)=O)cc1
InChI Key InChIKey=LRFKWQGGENFBFO-IBGZPJMESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 62 hits for monomerid = 23165
Affinity DataKi: 2.10nM ΔG°: -11.0kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 2.20nM ΔG°: -11.0kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataKi: 5.90nM ΔG°: -10.4kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataKi: 23nM ΔG°: -9.68kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nM ΔG°: >-7.60kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.10nMpH: 7.4Assay Description:Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMpH: 7.4Assay Description:Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 94nMAssay Description:Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin ...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at human S1P1 receptor expressed in RH7777 cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.280nMAssay Description:Induction of internalization of C-terminal GFP-fused human S1P1 receptor expressed in CHO cell membranes after 50 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0120nMAssay Description:Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.134nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.02nMAssay Description:Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human S1P2 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 27.8nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 22.2nMAssay Description:Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.360nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Agonist activity at human S1P2 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Agonist activity at human S1P3 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.360nMAssay Description:Agonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.370nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.290nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.340nMAssay Description:Agonist activity at human S1P5RMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Agonist activity at human S1P1 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.290nMAssay Description:Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.370nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as induction of GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 5.01nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells assessed as [35S]GTPgammaS binding after 3 hrs by radiometric assayMore data for this Ligand-Target Pair
Affinity DataEC50: 19.9nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells expressing beta-arrestin 2 after 105 mins by chemi-luminiscence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 63.1nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of c...More data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor c...More data for this Ligand-Target Pair
Affinity DataEC50: >3.16E+4nMAssay Description:Agonist activity at human S1P2 receptor expresssed in yeast MMY24 assessed as conversion of FDGlu to fluorescein after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at SIP3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at SIP1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHOK1 cell membranes by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHOK1 cell membranes by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.00800nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00700nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cell membranes assessed as stimulation of cAMP accumulation incubated for 10 mins by HTRF...More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0700nMAssay Description:Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated fo...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0200nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate r...More data for this Ligand-Target Pair
Affinity DataEC50: 3.60nMAssay Description:Agonist activity at human recombinant S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair