BDBM24464 N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-5-methyl-3-oxo-1-(2-oxopropyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide::Substituted Pyrazolone, 6

SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)=O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1

InChI Key InChIKey=GZMFYPWWSXGVTC-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24464   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24464(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  1.30nM ΔG°:  -12.0kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM24464(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataKi:  2nM ΔG°:  -11.7kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24464(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed