BDBM25058 (5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one::Compound I, rhodanine

SMILES COc1cc(O)cc(\C=C2/SC(=S)NC2=O)c1

InChI Key InChIKey=LSVTZBNOOSOZLV-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 25058   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5(Human)
Pfizer

LigandBDBM25058((5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 77.7nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
The University of Jordan

Curated by ChEMBL

LigandBDBM25058((5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 328nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL